A Vaccine for Ebola!

iStock_000046130062_MediumAt long last, a vaccine has been developed and tested that provides virtually total protection from Ebola virus infection, a great news study published in the Lancet has shown. Yay! Rick and I rejoice on PodMed this week.  Seems like it's been a long time coming, with thousands of people dying in rather horrific ways.

The study used a " open-label, cluster-randomised ring vaccination trial" design, with almost 8000 subjects from among people presumed to be exposed to someone with frank, confirmed Ebola virus infection. Briefly, some of the contacts were vaccinated immediately after their presumed exposure while others were vaccinated 21 days later. Development of Ebola virus disease in immediate and delayed vaccination groups was assessed, revealing 100% efficacy for the vaccine in preventing disease in those vaccinated immediately. Next steps will of course expand vaccination efforts and hopefully Ebola will be simply a blip on the landscape until the next viral illness emerges.  Other topics this week include restoring Circadian rhythm in persons who are totally blind with an eye toward alleviating insomnia, also in the Lancet, in Lancet Oncology a reduction in endometrial cancer risk with oral contraceptives, and management of anticoagulation in people with atrial fibrillation who may need stents, in the JACC.  Until next week, y'all live well.

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