Improving Kidney Transplants

iStock_000014270773_MediumIf you need a kidney transplant you've got a bunch of things to think about, and it would be great to check worries about kidney rejection off the list.  That may be possible with a new method for depleting antibodies from the blood of the recipient Rick and I talk about on PodMed this week, as published in the New England Journal of Medicine. The study uses an enzyme made by the bacterium Streptococcus pyogenes abbreviated IdeS to deplete the class of antibodies known as IgG.

Twenty-five people who required kidney transplantation were enrolled in this trial, 11 patients in Sweden and 14 in the US. All of them were highly sensitized, meaning they had high levels of antibodies that couldn't be depleted by other means. IdeS was able to eliminate IgG and another type of antibody entirely at the time of transplantation. Of the 25 kidneys transplanted, 24 functioned in the recipient. One transplanted kidney ultimately failed after antibodies other than the type depleted by the enzyme developed.

This study is good news for the many, many people who are waiting for kidneys on transplant lists as it allows kidneys that are not ideal from a matching standpoint to be received by folks with a bunch of antibodies on board. It may also prove useful for those who require two or more kidney transplants in their lifetime as they definitely become sensitized.

Other topics this week include Fees for Certification and Finances of Medical Specialty Boards in JAMA, Prescription Opioid Use, Misuse, and Use Disorders in U.S. Adults: 2015 National Survey on Drug Use and Health in Annals of Internal Medicine, and back to NEJM for Idarucizumab for Dabigatran Reversal. Until next week, y'all live well.

VN:F [1.9.17_1161]
Rating: 0.0/5 (0 votes cast)
No Comments

Leave a Comment

You can use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

Johns Hopkins Medicine does not necessarily endorse, nor does Johns Hopkins Medicine edit or control, the content of posted comments by third parties on this website. However, Johns Hopkins Medicine reserves the right to remove any such postings that come to the attention of Johns Hopkins Medicine which are deemed to contain objectionable or inappropriate content.

Previous post:

Next post: